The novel fungicide dibutylmorpholine, developed by Professor Qin Zhaohai of China Agricultural University, has received official registration.

Release Date:

2018-06-25

On April 23, 2018, the novel fungicide active ingredient pyrimorph and its 20% suspension concentrate, developed by Professor Qin Zhaohai’s research group at the College of Science, China Agricultural University, obtained official national pesticide registration. This milestone marks the first new agrochemical variety—entirely owned by China Agricultural University with fully independent intellectual property rights—to officially enter agricultural production. Pyrimorph (experimental code ZNQ-0317) is an acrylamide‑based fungicide containing a pyridine heterocycle, exhibiting excellent protective and curative efficacy against various crop diseases, including late blight, downy mildew, anthracnose, and tobacco black shank. Research indicates…

On April 23, 2018, the novel fungicide active ingredient diniconazole‑methyl and its 20% suspension concentrate, developed by Professor Qin Zhaohai’s research group at the College of Science, China Agricultural University, were granted national approval. Pesticide The official registration certificate marks the entry of the first new pharmaceutical variety—developed by China Agricultural University and possessing fully independent intellectual property rights in China—into the field of agricultural production.

　　Pyrimorph (experimental code ZNQ‑0317) is an acrylamide‑based fungicide containing a pyridine heterocycle, exhibiting excellent protective and curative activity against a wide range of crop diseases, including late blight, downy mildew, anthracnose, and tobacco black shank. Studies have demonstrated that it operates via a dual mode of action: it modulates the polar distribution of cell‑wall‑synthesizing components in fungal cells while simultaneously inhibiting the fungal energy‑production system. Notably, it is the first identified inhibitor of cytochrome c reductase (Complex III) in the mitochondrial respiratory chain belonging to the CAA class. This product is highly effective, exhibits low toxicity, demonstrates favorable environmental safety, and carries a low risk of resistance development, making it a highly desirable broad‑spectrum fungicide. Following expert evaluation organized by the Ministry of Education, this achievement has been recognized as being at an internationally advanced level.

Figure 1: Structural formula of dibutylmorpholine
　　In addition, on January 20, 2017, the novel insecticide piperidinyl‑guanidine developed by this research group also obtained a temporary registration certificate for both the active ingredient and its formulated products, and formal registration trials are currently underway. This product is a multi‑site‑action insecticide that combines the characteristics of neonicotinoids and sodium‑channel inhibitors, demonstrating excellent control efficacy against various pests such as aphids, rice planthoppers, psyllids, and small green leafhoppers, while exhibiting favorable safety profiles for environmental organisms like honeybees, thus holding broad prospects for practical application.

Author: College of Science, China Agricultural University Website Source: College of Science, China Agricultural University Website

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